Details of HTA journal title
Last updated: 31 August 2010 - Next update due: 7 September 2010
Research type: |
Primary Research (e.g. trial) |
Title (lead author) etc: |
A randomised controlled trial examining the longer-term outcomes of standard versus new antiepileptic drugs The SANAD trial (Marson) 145 pages, Volume 11, number 37 |
DOI |
10.3310/hta11370 |
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Outputs in journals arising from this project
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Headline: |
Trial provides evidence that lamotrigine may be a clinical and cost-effective alternative to the existing standard drug treatment, carbamazepine, for epilepsy patients diagnosed as having partial seizures. |
Project ref: |
95/13/01 |
Original project title: |
A randomised controlled trial of longer-term clinical outcomes and cost-effectiveness of standard and new antiepileptic drugs (SANAD) |
Chief Investigator: |
Professor David Chadwick, Professor of Neurology, Dept of Neurological Science, The Walton Centre for Neurology and Neurosurgery |
Project Website |
http://www.liv.ac.uk/neuroscience/sanad/ |
Start Date: |
September 1998 |
Date of publication in HTA journal series |
October 2007 |
Cost: |
£1,349,657 |
MeSH* index primary terms: |
EPILEPSY Q-drug-therapy; ANTICONVULSANTS Q-therapeutic-use (* = Medical Subject Headings) |
MeSH* index secondary terms: |
RANDOMIZED-CONTROLLED-TRIAL; CLINICAL-TRIAL; FOLLOW-UP-STUDIES; CARBAMAZEPINE Q-therapeutic-use; VALPROIC-ACID Q-therapeutic-use; COST-BENEFIT-ANALYSIS; TREATMENT-OUTCOME; HUMAN; COMPARATIVE-STUDY (* = Medical Subject Headings) |
ISRCTN* number: | ISRCTN 38354748 (*International Standard Randomised Controlled Trial Number) URL of this project on the Controlled Trials Website: http://www.controlled-trials.com/ISRCTN38354748 |
NRR* number, if applicable: |
N0484070422 (*National Research Register) The National Research Register was a public database of ongoing and recently completed research projects funded by, or of interest to, the United Kingdom's National Health Service (NHS). It is now an archive of projects from early 2000 to September 2007. Search the NRR archive. |
Project Protocol: |
Project protocol not available |
Printed copies of this title despatched: |
119 (Figures relate to the previous calendar month) |
Downloads/Views of electronic version from website: |
44146 (Figures are cumulative.) Last updated 27th July 2010. |
URL of this page: |
http://www.hta.ac.uk/1031 |
Outputs from this project
- Marson, A; Al-Kharusi, A; Alwaidh, M; Appleton, R; Baker, G; Chadwick, D; Cramp, C; Cockerell, O; Cooper, P; Doughty, J; Eaton, B; Gamble, C; Goulding, P; Howell, S; Hughes, A; Jackson, M; Jacoby, A; Kellett, M; Lawson, G; Leach, J; Nicolaides, P; Roberts, R; Shackley, P; Shen, J; Smith, P; Smith, P; Tudur Smith, C; Vanoli, A; Williamson, P. The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial. Lancet.
- Marson, A; Al-Kharusi, A; Alwaidh, M; Appleton, R; Baker, G; Chadwick, D; Cramp, C; Cockerell, O; Cooper, P; Doughty, J; Eaton, B; Gamble, C; Goulding, P; Howell, S; Hughes, A; Jackson, M; Jacoby, A; Kellett, M; Lawson, G; Leach, J; Nicoladides, P; Roberts, R; Shackley, P; Shen, J; Smith, D; Smith, P; Tudur Smith, C; Vanoli, A; Williamson, P. The SANAD study of effectiveness of carbamazepine, gabapentine, lamotrigine, oxcarbazepine or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial. Lancet.
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