HTA Programme - New Projects and Publications

Project: First-line therapy for adult patients with non-small cell lung cancer

Chief Investigator: Liverpool Reviews and Implementation Group (LRIG), University of Liverpool
Research Type: HTA Technology Assessment Report
ICD Chapters: Cancers
Key Areas: Cancer
Interventions: Cardiothoracic surgery, clinical oncology , radiology
ICD Diseases: Cancer of the lung
Research Type: HTA Technology Assessment Report
Expected publication date: Late 2011
HTA project ref: 09/126/01

Project: Trastuzumab for HER-2 positive advanced gastric cancer

Chief Investigator: Centre for Reviews and Dissemination (CRD), University of York
Research Type: NICE Evidence Review Group Report (ERG)
ICD Chapters: Cancers
Key Areas: Cancer
Interventions: Medical oncology
ICD Diseases: Cancer of stomach
Research Type: NICE Evidence Review Group Report (ERG)
Expected publication date: June 2010
HTA project ref: 08/219/01

Project: Combined anticoagulation and antiplatelet therapy for high-risk patients with atrial fibrillation: systematic review and individual patient meta-analysis

Chief Investigator: Dr Deirdre A Lane, Lecturer, University Department of Medicine, University of Birmingham and NHS
Research Type: Secondary Research (e.g. systematic review)
ICD Chapters: Vascular diseases
Key Areas: Heart disease
Interventions: Cardiology
ICD Diseases: Heart disease, other
Research Type: Secondary Research (e.g. systematic review)
Expected publication date: Mid 2012
HTA project ref: 09/11/02

Project: Upright maternal position in second stage labour in women with epidural analgesia; a randomised controlled trial

Chief Investigator: Professor Peter Brocklehurst, Director and Professor of Perinatal Epidemiology, National Perinatal Epidemiology Unit, University of Oxford
Research Type: Primary Research (e.g. trial)
ICD Chapters: Pregnancy and childbirth
Key Areas: Children, Emergency access, Primary care
Interventions: Midwife episode
ICD Diseases: Normal pregnancy
Research Type: Primary Research (e.g. trial)
Expected publication date: Late 2015
HTA project ref: 08/22/02

Project: Total or Partial Knee Arthroplasty Trial (TOPKAT)

Chief Investigator: Dr David John Beard, University Research Lecturer and RCUK Fellow, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford
Research Type: Primary Research (e.g. trial)
ICD Chapters: Bone and joint diseases
Key Areas: Older people
Interventions: Rheumatology
ICD Diseases: Osteoarthritis
Research Type: Primary Research (e.g. trial)
Expected publication date: Early 2018
HTA project ref: 08/14/08

Publication: Volume 14, number 11 (Cummins). Study found that continuous subcutaneous insulin infusion (CSII) provides some advantages over multiple daily injection (MDI) for both adults and children with type 1 diabetes mellitus, including better control of glucose levels, fewer problems with hypoglycaemia, and quality of life gains. However, there was no evidence that CSII is better than analogue-based MDI in type 2 diabetes mellitus or in gestational diabetes

Chief Investigator: Aberdeen HTA Group, University of Aberdeen
Research Type: NICE Technology Assessment Report (TAR)
ICD Chapters: Endocrine, nutritional and metabolic diseases
Key Areas: Diabetes, Public Health
Interventions: Endocrinology
ICD Diseases: Diabetes
Research Type: NICE Technology Assessment Report (TAR)
Publication date: 15/03/2010
HTA project ref: 06/61/01

Publication: Volume 14, number 10 (Hutchinson). Study found that gains may be made in clinical audit and evaluation through better understanding of the products of the different methods of review, and of the value of careful selection and training of reviewers

Chief Investigator: Professor Allen Hutchinson, Director of Public Health and Dep Dean of ScHARR, Department of Public Health, University of Sheffield
Research Type: Methodology
ICD Chapters: Methodology
Key Areas:
Research Type: Methodology
Publication date: 15/03/2010
HTA project ref: 06/91/02

Publication: Volume 14, number 9 (Hemingway). Study found that the most robust results for the prioritisation of patients awaiting coronary revascularisation relate to a strategy employing risk stratification using conventional clinical information together with a single biomarker (estimated glomerular filtration rate)

Chief Investigator: Professor Harry Hemingway, Professor of Clinical Epidemiology, Department of Epidemiology and Public Health, University College London
Research Type: Secondary Research (e.g. systematic review)
ICD Chapters: Vascular diseases
Key Areas: Heart disease, Public Health
ICD Diseases: Heart disease, other
Research Type: Secondary Research (e.g. systematic review)
Publication date: 15/03/2010
HTA project ref: 05/40/04