Research type:
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Primary Research (e.g. trial)
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Project title:
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Frequency of follow-up for patients with intermediate grade colorectal adenomas |
 Outputs in journals arising from this project
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Project ref: |
04/33/01 |
Cost: |
£542,058 |
Chief Investigator : |
Professor Wendy S Atkin, Professor in Gastrointestinal Epidemiology,
Department of Surgery and Cancer, Imperial College London
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Start Date: |
September 2006 |
Estimated date of publication in HTA journal series: |
Early 2012. This date takes account of time for report preparation and printing based on current average times for these activities.
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Plain English Summary |
This proposal intends to answer the question posed by examining the effect of extending intervals between follow-up colonoscopies in people found to have intermediate adenomas, as defined by the British Society of Gastroenterology guidelines (which were drawn up by the lead applicant). The study will use material from several high quality databases in hospitals or from bowel cancer screening initiatives to identify groups of patients with intermediate adenomas. The risk of cancer and severe adenomas will be assessed according to the interval between exams and the number, size and features of adenomas detected. This study should identify whether all patients with intermediate adenomas require surveillance and whether the intervals are of the appropriate length. It should also demonstrate how many follow-up exams are needed, and examine whether informing patients that they need to have colonoscopy surveillance distresses them in any way or whether they feel reassured as a result. A health economist will analyse the costs to individual patients and to the NHS and compare these with any potential benefits. |
Project Abstract: |
This proposal intends to answer the question posed by examining the effect of extending intervals between surveillance colonoscopies in people found to have intermediate adenomas, as defined by the British Society of Gastroenterology guidelines (which were drawn up by the lead applicant). The study will use data from several high quality databases in hospitals or from colorectal cancer screening initiatives to identify cohorts of patients in whom intermediate adenomas were detected and who have had a baseline colonoscopy. A survival analysis will be undertaken to estimate the risk of developing colorectal cancer in those who have had a baseline colonoscopy but no surveillance, according to baseline characteristics, such as age, sex and multiplicity, size and histopathological features of adenomas detected. Logistic regression will be used to analyse the risk of developing an advanced adenoma or cancer at follow-up according to the interval to follow-up and baseline characteristics.
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MeSH* index primary terms: |
COLORECTAL-NEOPLASMS Q-pathology; ADENOMA Q-pathology; COLONOSCOPY |
MeSH* index secondary terms: |
HUMANS; RISK-FACTORS; SURVIVAL-ANALYSIS; FOLLOW-UP-STUDIES; COHORT-STUDIES |
NRR* number, if applicable: |
N0484174400 (*National Research Register). The National Research Register was a public database of ongoing and recently completed research projects funded by, or of interest to, the United Kingdom's National Health Service (NHS). It is now an archive of projects from early 2000 to September 2007. Search the NRR archive.
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Project Protocol: |
Project protocol (pdf format, 555 kbytes)
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URL of this page: |
http://www.hta.ac.uk/1493 |
Outputs from this project
- Caffrey, F; Wong, J; Yen, A; Duffy, S; Atkin, W; Chen, T. Findings at Follow-up Endoscopies in subjects with suspected colorectal abnormalities: Effects of baseline finds and time to follow-up. The Cancer Journal volume 13, number4, July/August 2007.
- Cafferty, FH; Wong, J; Yen, AM; Duffy, SW; Atkin, WS; Chen, TH. Endoscopies in subjects with suspected colorectal abnormalities: Effect of baseline findings and time to follow up. Cancer Journal.
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