Direct link to this page: http://www.hta.ac.uk/1403

Details of HTA journal title

Last updated: 31 August 2010 - Next update due: 7 September 2010

Research type:

 Secondary Research (e.g. systematic review) 

Title (lead author) etc:

 A systematic review of the effectiveness of strategies for reducing the fracture risk in children with juvenile idiopathic arthritis with additional data on long-term risk of fracture and cost of disease management  (Thornton) 208 pages, Volume 12, number 3

DOI

 10.3310/hta12030
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Outputs in journals arising from this project

Headline:

 Bisphosphonates are a promising treatment for osteoporosis in children with juvenile idiopathic arthritis but the quality of the current evidence is poor and better studies are needed. 

This report should be referenced as follows:

 Thornton J, Ashcroft D, O'Neill T, Elliott R, Adams J, Roberts C, et al. A systematic review of the effectiveness of strategies for reducing the fracture risk in children with juvenile idiopathic arthritis with additional data on long-term risk of fracture and cost of disease management. Health Technol Assess 2008;12(3).

Project ref:

 03/43/04 

Original project title:

 A comparison of the effectiveness and cost-effectiveness of interventions for reducing the lifetime fracture risk in children with juvenile idiopathic arthritis - a systematic review with economic modelling 

Chief Investigator:

 Professor Deborah Pauline Mary Symmons, Prof Rheumatology and Musculoskeletal Epidemiology, ARC Epidemiology Unit, University of Manchester

Start Date:

 November 2004  

Date of publication in HTA journal series

 March 2008

Cost:

 £80,515 

MeSH* index primary terms:

 ARTHRITIS-JUVENILE-RHEUMATOID Q-complications; FRACTURES Q-etiology; VITAMIN-D Q-therapeutic-use; DIPHOSPHONATES Q-therapeutic-use (* = Medical Subject Headings)

MeSH* index secondary terms:

 HUMANS; RANDOMIZED-CONTROLLED-TRIAL; CLINICAL-TRIAL; RISK-FACTORS; CHILD; COST-BENEFIT-ANALYSIS; ARTHRITIS-JUVENILE-RHEUMATOID Q-economics; FRACTURES Q-economics; VITAMIN-D Q-economics; DIPHOSPHONATES Q-economics  (* = Medical Subject Headings)

NRR* number, if applicable:

 N0484152858 (*National Research Register) The National Research Register was a public database of ongoing and recently completed research projects funded by, or of interest to, the United Kingdom's National Health Service (NHS). It is now an archive of projects from early 2000 to September 2007. Search the NRR archive.

Project Protocol:

 Project protocol not available

Printed copies of this title despatched:

 103 (Figures relate to the previous calendar month)

Downloads/Views of electronic version from website:

 15096 (Figures are cumulative.) Last updated 27th July 2010.

URL of this page:

http://www.hta.ac.uk/1403

Outputs from this project

  • Thornton, J; Ashcroft, DM; Mughal, Z; Elliott, R; O'Neill, TW; Symmons, D. Systematic review of effectiveness of bisphosponates in treatment of low bone mineral density and fragility fractures in juenile idiopathic arthritis. Archives of Disease in Childhood.
  • Thornton, J; Ashcroft, DM; Mughal, MZ; Elliott, R; O'Neill, T; Symmons, D. Systematic review of effectiveness of bisphosphonates in treatment of low bone mineral density and fragility fractures in juvenile idiopathic arthritis. Archives of Disease in Childhood.
  • Thornton, J; Lunt, M; Ashcroft, DM; Baildam, E; Foster, H; Davidson, J; Garner-Medwin, J; Beresdord, M; Symmons, DPM; Thomson, W; Elliott, RA. Costing juvenile idiopathic arthritis: examining patient-based costs during the first year after diagnosis. Rheumatology (Oxford). 2008 Jul;47(7):985-90. Epub 2008 Apr 16..
Tue, 31 Aug 2010 16:14:07 +0100

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