Details of HTA journal title
Last updated: 31 August 2010 - Next update due: 7 September 2010
Research type: |
Primary Research (e.g. trial) |
Title (lead author) etc: |
Neuroleptics in the treatment of aggressive challenging behaviour for people with intellectual disabilities: a randomised controlled trial (NACHBID) (Tyrer) 76 pages, Volume 13, number 21 |
DOI |
10.3310/hta13210 |
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Outputs in journals arising from this project
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Headline: |
Study found that, contrary to findings of recent studies, neuroleptic drug treatment of aggressive behaviour in adults with intellectual disability conferred no significant benefits and that placebo treatment was a more cost-effective option |
This report should be referenced as follows: |
Tyrer P, Oliver-Africano P, Romeo R, Knapp M, Dickens S, Bouras N, et al. Neuroleptics in the treatment of aggressive challenging behaviour for people with intellectual disabilities: a randomised controlled trial (NACHBID). Health Technol Assess 2009;13(21). |
Project ref: |
01/07/02 |
Original project title: |
Neuroleptics in adults with aggressive challenging behaviour and intellectual disability (NACHBID) |
Chief Investigator: |
Professor Peter Tyrer, Professor of Community Psychiatry, Centre for Mental Health, Imperial College London |
Start Date: |
August 2002 |
Date of publication in HTA journal series |
April 2009 |
Cost: |
£630,943 |
MeSH* index primary terms: |
ANTIPSYCHOTIC-AGENTS Q-therapeutic-use; MENTAL-DISORDERS Q-drug-therapy; AGGRESSION Q-drug-effects (* = Medical Subject Headings) |
MeSH* index secondary terms: |
HUMAN; ADULT (* = Medical Subject Headings) |
ISRCTN* number: | ISRCTN 11736448 (*International Standard Randomised Controlled Trial Number) URL of this project on the Controlled Trials Website: http://www.controlled-trials.com/ISRCTN11736448 |
NRR* number, if applicable: |
N0484114811 (*National Research Register) The National Research Register was a public database of ongoing and recently completed research projects funded by, or of interest to, the United Kingdom's National Health Service (NHS). It is now an archive of projects from early 2000 to September 2007. Search the NRR archive. |
Project Protocol: |
Project protocol (pdf format, 172 kbytes) |
Printed copies of this title despatched: |
137 (Figures relate to the previous calendar month) |
Downloads/Views of electronic version from website: |
8196 (Figures are cumulative.) Last updated 27th July 2010. |
URL of this page: |
http://www.hta.ac.uk/1322 |
Outputs from this project
- Tyrer, P; Cooray, S,. Put knowledge before ignorance. Community Care July 15th 2005.
- Crawford, M; Oliver, PC; Rao, B; Reece, B; Tyrer, P,. Modified Overt Aggression Scale (MOAS) for people with intellectual disability and aggressive challenging behaviour: a reliability study. Journal of Applied Research in Intellectual Disabilities,20(4)368-372.
- Tyrer, P; Oliver-Africano, PC; Ahmed, Z; Bouras, N; Cooray, S; Deb, S; Murphy, D; Hare, M; Meade, M; Reece, B; Kramo, K; Bhaumik, S; Harley, D; Regan, A; Thomas, D; Rao, B; North, B; Eliahoo, J; Karatela, S; Soni, A; Crawford, M. Risperidone, haloperidol and placebo in the treatment of aggressive challenging behaviour in intellectual disability: randomised controlled trial.. Lancet, Volume 371, Issue 9606, Pages 57 - 63, 5 January 2008.
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