Details of HTA published project
Research type: |
Primary Research (e.g. trial) |
Title (lead author) etc: |
Topical or oral ibuprofen for chronic knee pain in older people. The TOIB study (Underwood) 176 pages, Volume 12, number 22 |
DOI |
10.3310/hta12220 |
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This publication is now a part of the NIHR Journals Library. Documents relating to the publication can be found at the corresponding journal issue page, which is at the following link: 
http://www.journalslibrary.nihr.ac.uk/hta/volume-12/issue-22
Outputs from this project
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Headline: |
Study on whether GPs should advise their older patients with chronic knee pain to use topical or oral non-steroidal anti-inflammatory drugs (NSAIDs) found that oral NSAIDs appear to produce more minor adverse effects than topical NSAIDs. |
This report should be referenced as follows: |
Underwood M, Ashby D, Carnes D, Castelnuovo E, Cross P, et al. Topical or oral ibuprofen for chronic knee pain in older people. The TOIB study. Health Technol Assess 2008;12(22). |
Project ref: |
01/09/02 |
Original project title: |
Are topical or oral Ibuprofen equally effective for the treatment of chronic knee pain in older people (Topical or Oral Ibuprofen TOIB) |
Chief Investigator: |
Professor Martin Underwood, Professor of Primary Care Research, Warwick Medical School Clinical Trials Unit, University Hospitals NHS Trust |
Start Date: |
July 2002 |
Date of publication in HTA journal series (now NIHR Journals Library) |
May 2008 |
Cost: |
£725,617 |
MeSH* index primary terms: |
ARTHRALGIA Q-drug-therapy; IBUPROFEN Q-therapeutic-use; ANALGESICS-NON-NARCOTIC (* = Medical Subject Headings) |
MeSH* index secondary terms: |
HUMAN; RANDOMIZED-CONTROLLED-TRIAL; CLINICAL-TRIAL; QUESTIONNAIRES; KIDNEY Q-physiology; HEMOGLOBINS Q-analysis; FERRITIN Q-analysis; BLOOD-PRESSURE; LUNG Q-physiology (* = Medical Subject Headings) |
ISRCTN* number: | ISRCTN 79353052 (*International Standard Randomised Controlled Trial Number) URL of this project on the Controlled Trials Website: http://www.controlled-trials.com/ISRCTN79353052 |
NRR* number, if applicable: |
N0484112114 (*National Research Register) The National Research Register was a public database of ongoing and recently completed research projects funded by, or of interest to, the United Kingdom's National Health Service (NHS). It is now an archive of projects from early 2000 to September 2007. Search the NRR archive. |
Project Protocol: |
Project protocol (pdf format, 171 kbytes) |
URL of this page: |
http://www.hta.ac.uk/1302 |
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