Direct link to this page: http://www.hta.ac.uk/1230

Details of HTA project in progress

Last updated: 1 February 2012 - Next update due: 8 February 2012

Research type:

 Primary Research (e.g. trial)  

Project title:

 The ProtecT trial - evaluating the effectiveness of treatments for clinically localised prostate cancer 
Outputs in journals arising from this project

Project ref:

 96/20/99 

Cost:

 £34,193,704 This project has been commissioned by the HTA Programme on behalf of the Department of Health 

Chief Investigator :

 Professor Freddie Hamdy, Nuffield Professor of Surgery, John Radcliffe Hospital, University of Oxford

Project Website

 http://www.epi.bris.ac.uk/protect

Project Email

info-protect@bristol.ac.uk 

Start Date:

 June 2001  

Estimated date of publication in HTA journal series:

Early 2015. This date takes account of time for report preparation and printing based on current average times for these activities.  

Project Abstract:

 The overall aim is to evaluate the effectiveness, cost-effectiveness and acceptability of treatments for men with localised prostate cancer within the context of a pragmatic randomised controlled trial. This will compare 3 treatments (active monitoring, radical prostatectomy and radical radiotherapy). Specific objectives are as follows:
1) To assess survival at 5, 10 years and 15 years following treatment
2) To investigate a number of short and medium-term outcomes, including: disease progression (biochemical and clinical), treatment complications, lower urinary tract symptoms, psychosocial impact of case-finding and treatment, including generic health status, quality of life and sexual function
3) To estimate the resource use and costs of case-finding, treatment and follow-up, and to compare costs and outcomes of treatment in terms of survival and health related quality of life.
4) To collect material suitable for basic science research, and develop a network for collaborative research.  

MeSH* index primary terms:

 PROSTATIC-NEOPLASMS Q-surgery; PROSTATIC-NEOPLASMS Q-radiotherapy; PROSTATECTOMY Q-methods; COMBINED-MODALITY-THERAPY; COSTS-AND-COST-ANALYSIS 

MeSH* index secondary terms:

 HUMAN; TREATMENT-OUTCOME; MALE; MIDDLE-AGE; AGED; RANDOMIZED-CONTROLLED-TRIAL; CLINICAL-TRIAL; QUALITY-OF-LIFE; SURVIVAL-ANALYSIS; DISEASE-PROGRESSION; COMPARATIVE-STUDY; FOLLOW-UP-STUDIES 

NRR* number, if applicable:

 N0484104336 (*National Research Register). The National Research Register was a public database of ongoing and recently completed research projects funded by, or of interest to, the United Kingdom's National Health Service (NHS). It is now an archive of projects from early 2000 to September 2007. Search the NRR archive.

ISRCTN* number:

ISRCTN 20141297 (*International Standard Randomised Controlled Trial Number) 
URL of this project on the Controlled Trials Website:
http://www.controlled-trials.com/ISRCTN20141297 

Project Protocol:

 Project protocol not available

URL of this page:

http://www.hta.ac.uk/1230

Outputs from this project

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